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The idea of healthy, non-diabetic people using CGMs to further optimize their health is having a moment. But it鈥檚 not without controversy. (Photo: Courtesy Supersapiens)
Sweat Science

A Real-Time Fuel Gauge for Endurance Athletes

Supersapiens鈥檚 new continuous glucose monitor promises to help athletes manage their energy levels. But can it really stave off a bonk?

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(Photo: Courtesy Supersapiens)

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Before last year鈥檚 World Half Marathon Championships in Gdynia, Poland, a young British distance runner named Jake Smith had a call with scientists from a small company his agent had connected him with. They鈥檇 crunched the data from his performance two weeks earlier at the London Marathon, where he鈥檇 struggled in his assigned role as a pacer, and had a simple message for him: 鈥淭hey literally said, 鈥榊ou need to eat more,鈥欌 he recalls.

On the back of his upper right arm, the 22-year-old was wearing a circular adhesive patch about an inch across, with a tiny filament embedded into his flesh. It was a continuous glucose monitor, or CGM鈥攁 device designed to track real-time blood sugar (also known as glucose) levels in diabetics, repurposed for athletes by an Atlanta-based start-up called in collaboration with the medical device giant Abbott. The data Smith uploaded after London showed that his glucose levels had started at a middling level and then declined steadily during the race. 鈥淏y about ten or 11 miles, I was like, 鈥楾his shouldn鈥檛 feel like this,鈥欌 he says. So in Poland on the day before the race, he chowed down on pasta, rice, chicken, vegetables, and fruit, and he kept a wary eye on the Supersapiens app on his phone. Whenever his levels started to dip, he ate more.

The next morning, after a breakfast of two bagels with Nutella, , and peanut butter, he took on the world鈥檚 best distance runners. His time of 1:00:31 was a massive personal best, smashing his own British under-23 record and good for 18th place overall. And his glucose levels鈥攚ell, no one knows, because they were so high that they maxed out the sensor throughout the race. 鈥淭hey said they would love to know,鈥 Smith says, 鈥渂ut the app just wouldn鈥檛 go any higher.鈥


In late 2019, I got a LinkedIn message from a guy named Brian Davis who wanted to meet for coffee and tell me about a company he and his partners were launching. The pitch, he told me after I鈥檇 signed the requisite NDA, was 鈥渢he world鈥檚 first human fuel gauge.鈥 The body runs on glucose, he explained, and a CGM would give athletes real-time insight in how well fueled they were and when and what they should eat.

Davis was in Toronto, where I live, to meet with a York University researcher named Michael Riddell, who is among the world鈥檚 leading experts on how people with diabetes respond to exercise. Diabetes is fundamentally a problem with glucose control, thanks to the absence or ineffectiveness of insulin, the body鈥檚 main tool for shunting glucose out of the blood and into your muscle or fat cells. The development and refinement of CGMs over the past decade has had a huge impact on the ability of people with diabetes to keep their glucose levels within a safe range. In particular, they鈥檝e been crucial for , a pro cycling team whose members all have Type 1 diabetes鈥攏ot just for the health and safety of the riders, but also for their performance. That was the insight that led Phil Southerland, co-founder of the cycling team, to launch Supersapiens in 2019. After all, he figured, athletes with diabetes aren鈥檛 the only ones who worry about bonking.

The idea of sticking CGMs on healthy people isn鈥檛 totally unprecedented. In fact, when I wrote about blood sugar levels in endurance athletes back in 2017, the podcaster and physician Peter Attia praised his CGM as 鈥渙ne of the most informative inputs I鈥檝e had in my life.鈥 But Supersapiens faced a couple of significant obstacles to their goal of selling to athletes. One was regulatory: in most places around the world, you need a prescription to get a CGM. When I met with Davis in 2019, they were hoping to get approval for non-prescription sales by mid-2020. Supersapiens ended up launching in Europe last fall, but remains unavailable in the United States. Thanks in part to COVID-related delays at the Food and Drug Administration, it probably 飞辞苍鈥檛 be approved until next year.

The other obstacle鈥攚hich is, if anything, even knottier鈥攊s that the link between blood sugar and performance is really complicated. We鈥檙e not like cars, which simply run on gas until the tank is empty. Instead, our muscles run on a complex mix of fuels鈥攏ot just fat and carbohydrate, but various forms of fat and carbohydrate (of which glucose is just one) stored in various places (of which the bloodstream is also just one), in a blend that depends on the intensity and duration of the task and the relative level of the various fuel tanks. And if glucose levels are complicated in people with diabetes, buffeted by stress and fatigue and hydration and dozens of other factors, they鈥檙e even more complicated in non-diabetics thanks to the action of insulin. Just because you have low blood sugar, in other words, that 诲辞别蝉苍鈥檛 mean you鈥檙e about to bonk. And conversely, just because you have high blood sugar, that 诲辞别蝉苍鈥檛 mean you 飞辞苍鈥檛 bonk.

Still, Supersapiens鈥 pitch is that some information is better than none. Perhaps the heartiest endorsement of this pitch came in June, when the Union Cycliste Internationale, cycling鈥檚 worldwide governing body, banned the use of glucose monitors in competition鈥攁 ban that currently applies almost exclusively to Supersapiens, and implicitly assumes that knowing your glucose levels gives you a competitive edge. 鈥淭he fans don鈥檛 want to see Formula One in bike racing,鈥 UCI innovations manager Mick Rogers . 鈥淭hey want surprises. They want unpredictability.鈥

Meanwhile, Supersapiens has signed partnership deals with World Tour cycling teams including Canyon-SRAM and Ineos (who can still use the CGMs in training) and the triathlon team BMC-Vifit, and will be the title sponsor for this year鈥檚 Ironman World Championships in Hawaii, where they鈥檙e still allowed in competition. They鈥檝e also enrolled more than 400 pro athlete ambassadors, including luminaries like Kenyan marathoner Eliud Kipchoge, all of whom are uploading their data to the company for analysis. 鈥淕lucose levels in non-diabetics? We鈥檙e all a little unfamiliar with that,鈥 admits Riddell, who is now a scientific advisor to the company. Elite-level training and racing adds another twist that makes this data trove unlike anything previously analyzed, he says: 鈥淪ometimes it鈥檚 high; other times, it鈥檚 quite low. It鈥檚 not abnormal, but it鈥檚 extreme.鈥

To observers like , a widely respected sports scientist at the Canadian Sport Institute Pacific with particular expertise in sports nutrition and metabolism, the biggest challenge for Supersapiens will be extracting actionable advice from this firehose of data. To that end, the company has recently hired ten more full-time scientists, bringing its science team to 12 out of a total headcount of over 70. Those researchers are getting tantalizing glimpses of, say, the minute-by-minute ebb and flow of glucose in Kipchoge鈥檚 bloodstream during this spring鈥檚 Hamburg Marathon. But can that data tell Kipchoge anything about what he should do differently next time? 鈥淚鈥檓 sure the unit measures accurately,鈥 Stellingwerff says. 鈥淏ut my main question is: Why?


You鈥檝e only got about a teaspoon of sugar in your bloodstream, and your body is carefully engineered to keep it that way. Eat a triple scoop of ice cream, and your pancreas will release insulin to stash the extra sugar into your muscle and fat cells. Get chased by a lion, and stress hormones will trigger a surge of glucose from the liver into your bloodstream to give your muscles the quick fuel they need to fight or flee. During exercise, your muscles burn through glucose 100 times faster than they do at rest, but the delicate balance between supply and demand mostly keeps levels in your bloodstream within a tight range between about 70 and 140 milligrams per deciliter. That鈥檚 why you can鈥檛 simply assume that low glucose levels mean you鈥檙e running out of fuel.

The key sources of energy for endurance are carbohydrates and fat, each of which can be stored in the muscles themselves or in the bloodstream. Here鈥檚 a graph, from , that shows the fuel mixture at different exercise intensities. Muscle glycogen and muscle triglycerides are carbohydrate and fat, respectively, stored in the muscle; plasma FFA (free fatty acids) and plasma glucose are fat and carbohydrate, respectively, circulating in the bloodstream.

Chart of fuel mixture at different exercise intensities
(Photo: Nature Metabolism)

At the lowest intensity, equivalent to an easy walk, fat provides nearly all of the fuel. At the highest intensity, equivalent to a brisk run, you鈥檙e burning mostly carbohydrate, but predominantly in the form of muscle glycogen rather than glucose. Looking at a graph like this, you might wonder why anyone would care about glucose levels.

But if you stay on the bike or out on the trails for long enough, the picture gradually changes. You can only store enough glycogen in your muscles to fuel hard exercise for somewhere around 90 to 120 minutes. As those supplies dwindle, you begin to rely more on glucose. Here鈥檚 , based on studies by University of Texas researcher Edward Coyle and others during the 1970s and 1980s, showing how the fuel mix shifts during prolonged exercise:

Chart of how the fuel mix shifts during prolonged exercise
(Photo: International Journal of Sports Medicine)

After three or four hours, you鈥檙e burning 40 percent glucose鈥攐r at least, you are if you can keep your glucose levels high enough with sports drinks, gels, and other sources. If you just drink water, your glucose levels will drop, and performance will suffer. This is the observation, laid out by Coyle in , that underlies the entire sports drink industry.

Gatorade鈥檚 message is blunt: drink as much sports drink as you can so that, God forbid, your glucose levels will never drop. Supersapiens has a more nuanced message: drink or eat only as much as you need. After all, downing gels or drinks on the run costs time and often leads to an upset stomach or worse. We each have an optimal performance zone, neither too low nor too high, which we can discover by trial and error. 鈥淏elow 110, I struggle to do longer rides,鈥 says Southerland. 鈥淎t 140 to 180 I feel best. But these levels are very personalized.鈥 Smith鈥檚 zone looks more like a straight line, since he ran his breakthrough half-marathon almost entirely above 200 mg/dL, the upper threshold for the app. Kipchoge鈥檚 data remains confidential, but Todd Furneaux, the company鈥檚 president, is willing to speak in general terms: 鈥淎ll of our very elite athletes, when they鈥檙e running, even in an Ironman, they鈥檙e in the 180 to 200 range. They鈥檙e flatlining.鈥

The sensor that Abbott produces for Supersapiens is called the Libre Sense, and it鈥檚 billed as a 鈥済lucose sport biosensor.鈥 In most respects, it seems to be identical to the FreeStyle Libre 2 CGM marketed to people with diabetes, but there are a few key tweaks. The sport version sends minute-by-minute updates to the app (or to a forthcoming wrist display) via Bluetooth, compared to a 15-minute interval in the regular model. And the measurement range is capped at 200 mg/dL, much lower than what you鈥檇 need to safely monitor your levels with diabetes鈥攑resumably an attempt to reassure regulators that it 飞辞苍鈥檛 be used as a medical device. The devices currently sell for 65 euros (roughly $77), and each unit lasts for 14 days once you apply it to your arm.

The fact that athletes like Smith are blowing the upper limit away is one indicator that the real-world data from athletes isn鈥檛 quite what the company expected. 鈥淚nitially, we thought it was all about how to avoid a bonk,鈥 Furneaux says. That idea may still have merit: in that collected CGM data during exercise from people without diabetes, Riddell notes that some people dropped well below 70 mg/dL, a range he says is associated with clear impairment of cognitive and physical function. Wearing a CGM might have warned these people that they needed more fuel, leading to better performance, though this claim hasn鈥檛 been tested.

It鈥檚 not clear whether the same observation applies to elite athletes, though. Louise Burke, an exercise nutrition researcher at Australian Catholic University who has worked closely with Australia鈥檚 Olympic teams for four decades, has seen athletes drop below 50 mg/dL with no apparent ill effects, while others show clear symptoms at around 75. 鈥淚t may depend on the caliber of athlete,鈥 she says. 鈥淩eally elite athletes sometimes seem to be able to push lower. But basically we just don鈥檛 know.鈥

It鈥檚 not just about the bonk, though. Burke ran a study earlier this year with 14 elite Australian racewalkers to explore whether CGMs could pick up warning signs of chronic low energy availability, which is linked to health problems and overtraining. The myriad factors that make glucose levels bounce up and down during the day make it hard to draw meaningful conclusions, but Burke figures that the overnight levels when you鈥檙e sleeping might give a clearer signal of whether you鈥檙e getting enough calories to fuel your training. The results haven鈥檛 yet been analyzed, so for now Burke is interested but unconvinced. 鈥淚鈥檓 not saying it鈥檚 not going to be useful,鈥 she says, 鈥渂ut I鈥檓 just saying it needs validation.鈥

Another possibility is using the CGM to fine-tune your carbohydrate loading before a major race, like Jake Smith, the British half-marathoner, did. Modern protocols generally involve a couple of days of very high carbohydrate intake to ensure that your muscles are fully stocked with glycogen at the start line. But the target of works out to about 16 cups of cooked pasta for a 150-pound athlete, which is no easy feat. You can鈥檛 use a CGM to directly measure your glycogen stores, but the Supersapiens app gives you a trailing 24-hour glucose average. That number could turn out to be a proxy for muscle glycogen stores, Furneaux says, because if it鈥檚 higher than normal, it means the excess glucose has nowhere else to go.

The last few hours before a workout or race can also be tricky. In as many as 30 percent of endurance athletes, a phenomenon called causes temporary feelings of light-headedness and weakness after a few minutes of exercise. The apparent culprit: eating simple carbohydrates 30 to 60 minutes before exercise, which triggers a rise in insulin levels that lingers for an hour or two. When you start exercising, you then have two different levers鈥攊nsulin and exercise鈥攖rying to lower your glucose levels at the same time, causing them to drop too rapidly. 鈥淲e see this a lot in the Supersapiens data,鈥 Riddell says. 鈥淧eople are not fueling properly.鈥 One countermeasure is to eat only in the last five to ten minutes before exercise, so your insulin levels don鈥檛 have time to rise. But wearing a CGM also gives you the option of figuring out exactly how your glucose levels respond to different types of food and different pre-workout timings.


Lots of novel and fascinating potential uses? Check. But what about actual evidence that sticking one of these things on your arm will make you faster? Abbott鈥檚 promises that it will 鈥渋nform athletes about how to fuel appropriately, to fill their glycogen stores prior to a race and to know when to replenish during a race to maintain athletic performance.鈥 Follow the relevant footnotes, and one leads to about the importance of refueling after exercise, while the other leads to in which four national-class swimmers wore a CGM for a week, with no intervention or performance measures.

Of course, the published literature sometimes lags behind elite practice. I emailed Armand Bettonviel, the Dutch sports nutritionist who was credited with , to get his take. Bettonviel is currently using Supersapiens with and three other athletes, but the first thing he emphasized was that interpreting data from the CGM is 鈥渘ot yet hard science.鈥 He鈥檚 using it to build up a more data-driven picture of the various ways that Kipchoge鈥檚 body produces and uses glucose, and how they change under different conditions. Those general insights then allow him to drill down into the specifics of Kipchoge鈥檚 in-race drinking protocol, which was meticulously optimized during his sub-two-hour marathon attempts.

There are caveats, though. Bettonviel wants to determine Kipchoge鈥檚 鈥渙ptimal blood glucose range,鈥 and figure out the best pre-race and in-race fueling protocol to keep him there. But any good endurance athlete also needs to be able to burn fat efficiently: 鈥淚 also strongly believe that metabolic flexibility could be a key performance indicator,鈥 Bettonviel says. 鈥淎ll changes made based on blood glucose values could potentially affect this flexibility.鈥 Moreover, he鈥檚 finding that what鈥檚 true for Kipchoge鈥檚 glucose responses isn鈥檛 necessarily true for the other athletes, making it difficult to formulate general rules. 鈥淥ur team is still learning and analyzing,鈥 he says. 鈥淲e don鈥檛 jump to conclusions yet and any changes made are small ones.鈥

Of the exceedingly scant data in the published literature on athletes wearing CGMs, virtually all of it focuses on health rather than performance. Most notably, another Swedish study had 15 national-team endurance athletes wear a CGM for up to two weeks. Compared to non-athlete controls, they spent more time below the normal glucose threshold of about 70 mg/dL, mostly in the middle of the night; and they also spent more time above the upper threshold of about 140 mg/dL, mostly during the early afternoon. During their training sessions, on the other hand, they generally stayed within the normal range.

The idea of healthy, non-diabetic people using CGMs to further optimize their health is indeed . But it鈥檚 not without controversy. When Supersapiens announced its this spring, Tom Hughes, a medical doctor and sports science lecturer at Leeds Beckett University in Britain, . 鈥淚 don鈥檛 think I have seen any evidence that blood glucose drops significantly during an Ironman,鈥 he says鈥攁 claim that he鈥檚 tested on himself at least five times, taking old-school finger-prick readings of blood glucose when he felt he was bonking and observing levels well over 100 mg/dL. And he also isn鈥檛 convinced that obsessively tracking the peaks and valleys of your glucose readout during the day will tell you anything useful about your health. Instead, he says, it鈥檚 simply an opportunity to 鈥渟tress about another number we don鈥檛 understand.鈥

To my surprise, even Riddell, the diabetes researcher and Supersapiens scientific advisor, admits some sympathy for this perspective. 鈥淭he obsession with numbers is worth writing about,鈥 he says. 鈥淓ven among people with diabetes, the patient is often the one who 诲辞别蝉苍鈥檛 want the CGM.鈥 After all, you now have a stream of non-stop data that seems to be judging you, often negatively, after every meal and snack. And when you try to 鈥渇ix鈥 your behavior, your glucose levels don鈥檛 always respond in the way you expect. Riddell and his colleagues have identified at least 40, and perhaps as many as 200, different factors that influence glucose, making it tricky to sort out which signals really matter. If the device is going to catch on as an athletic aid, he says, Supersapiens 鈥渘eeds to be better at the 鈥榮o what?鈥欌

That鈥檚 easier said than done, but it鈥檚 why the company鈥檚 12 scientists are poring through the data from their athlete ambassadors, looking for patterns and trends and telltale signals鈥攁nd perhaps even new science. Already the data is yielding a changed understanding of what glucose looks like in serious athletes. The conventional view is that glucose values stay in the normal range even during hard training, as seen in the Swedish study. No one expected the sky-high values that Jake Smith and others produce during competition. 鈥淢edical textbooks say 鈥榞lucose homeostasis is unperturbed by exercise in non-diabetics,鈥欌 says Riddell. 鈥淭hat鈥檚 wrong! We know that! So it鈥檚 50 years out the window. We鈥檙e going to rewrite the textbook.鈥

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