Our ability to edit genetic material took a听huge leap forward in 2012 with the development of a gene editing tool听called CRISPR (which stands for听'clustered regularly-interspaced short palindromic repeats'.)听Cheap and relatively easy to use, CRISPR, as , lets 鈥渟cientists cut and paste specific portions of DNA, offering a path to new treatments or cures for genetic diseases.鈥
Labs across the world are already using what many have been calling a Nobel Prize-worthy discovery, and 厂肠颈别苍肠别听magazine just voted CRISPR its 2015 鈥淏reakthrough of the Year.鈥 It鈥檚 so quickly advancing the ability to alter genes that it even prompted an in Washington, D.C., earlier this month, where the world鈥檚 leading geneticists听debated the ethics behind its potential uses.听
But while gene editing technology has been evolving faster than anyone could鈥檝e imagined just a few years ago, the days when we鈥檒l be able to make ourselves innately faster, stronger, and more resilient, says Stanford genetics professor Dr. Stuart Kim, are still far enough off, they might as well be the stuff of science-fiction.
鈥淚t鈥檚 only barely possible to cure a disease right now.听Not to make people better, but to cure a genetic disease, and that鈥檚 just starting.鈥
鈥淚t鈥檚 only barely possible to cure a disease right now,鈥 says Kim, who runs his own eponymous lab at Stanford, focused on the genetics of aging. 鈥淣ot to make people better, but to cure a genetic disease, and that鈥檚 just starting.鈥 Current research is largely focused on single-gene disorders, or illnesses thought to be caused by a single mutated gene, like Huntington鈥檚, or SCID aka Bubble Boy disease. It鈥檚 easier for scientists to home听in on the fix, and to expect a positive outcome once the problem gene is repaired.听
On the other hand, treatments that would interest healthy athletes by increasing resistance to muscular injury or stress fractures, for example, will likely involve multiple genes, and figuring out how altering one might affect the behavior of others is a puzzle that could take decades to put together. 鈥淭here is a need to understand the risks,鈥 the gene editing summit鈥檚 organizing committee concluded, including the possibility that the editing technique itself could be inaccurate, sometimes missing its intended target. Or that altering one gene could cause a life-threatening chain reaction.听
But while the invention of an injury-proofing serum might be a fantasy for now, using genes to optimize athleticism is not. Services like can now map parts of your genome for a few hundred dollars, and scholars like Dr. Kim and his colleagues are starting to make sense of some of that information鈥攅nough to provide actionable advice to athletes.听
For example, Kim鈥檚 lab has been conducting DNA studies of 900 Stanford varsity athletes in 30 different sports. 鈥淚 want to look at their DNA and at their injuries and see if we can see the difference between guys who get injured and guys who didn鈥檛 get injured and thereby make a DNA diagnostic that you could use in the pre-season,鈥 Kim says.听
Scientists have already linked certain genes to a higher risk of stress fracture, Kim points out. That knowledge might encourage a runner, for example, to incorporate more cross-training into his or her听program.听
Using genetic information to guide training and avoid injury isn鈥檛 the same as injecting a magic bone-strengthening elixir, but it鈥檚 a start鈥攐ne that should thrill data-driven athletes. 鈥淟ooking at who you are personally and trying to tune your training,鈥 Kim says, 鈥渢hat鈥檚 pretty realistic.鈥